Hydrogen borrowing catalysis using 1° and 2° alcohols: Investigation and scope leading to ? and ? branched products
نویسندگان
چکیده
The alkylation of a variety ketones using 1° or 2° alcohols under hydrogen borrowing catalysis is described. Initial research focused on the ?-alkylation cyclopropyl with higher (i.e. larger than MeOH), leading to formation ?-branched products. Our search for additional substrates which explore this chemistry led us discover that di- ortho -substituted aryl were also privileged scaffolds, Ph? (C 6 Me 5 ) being optimal choice. Further investigations revealed motif was crucial forming ?-branched products, provided an opportunity study diastereoselective and intramolecular processes.
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ژورنال
عنوان ژورنال: Tetrahedron
سال: 2021
ISSN: ['0040-4020', '1464-5416']
DOI: https://doi.org/10.1016/j.tet.2021.132051